Continuous-Flow Mechanical Cell Disintegrator

Complications of Continuous-Flow Mechanical Circulatory Support Devices

Left ventricular assist devices (LVADs), more importantly the continuous-flow subclass, have revolutionized the medical field by improving New York Heart Association (NYHA) functional class status, quality of life, and survival rates in patients with advanced systolic heart failure. From the first pulsatile device to modern day continuous-flow devices, LVADs have continued to improve, but they ...

A bubble-gating flow cell for continuous-flow analysis.

A system is described which permits measurements,such as photometry, to be made on air-segmented streams, as in continuous-flow analysis. Elimination of -the “debubbler” step before measurement provides two basic assets: (1) more rapid attainment of steady-state conditions (lower interaction between samples), and (2) maintenance of the integrity of the bubbled analysis stream, permitting subseq...

Furrow geometry nnder surge and continuous flow

Continuous mechanical contraction modulates expression of alveolar epithelial cell phenotype.

We have previously reported that mechanical distention of alveolar epithelial type II cells in culture favored the expression of the type I cell phenotype and inhibited the expression of the type II cell phenotype. The objective of the present study was to investigate the effects of continuous mechanical contraction on the expression of specific markers for the type I and type II cell phenotype...

Mechanical control of cell flow in multicellular spheroids.

Collective cell motion is observed in a wide range of biological processes. In tumors, physiological gradients of nutrients, growth factors, or even oxygen give rise to gradients of proliferation. We show using fluorescently labeled particles that these gradients drive a velocity field resulting in a cellular flow in multicellular spheroids. Under mechanical stress, the cellular flow is drastic...